Sunday, 22 April 2012

Scientists Tailor Cell Surface Targeting System to Hit Organelle ZIP Codes

Scientists who developed a technology for identifying and targeting unique protein receptor ZIP Codes on the cellular surface have found a way to penetrate the outer membrane and deliver engineered particles -- called iPhage -- to organelles inside the cell.

This new capacity was used to screen for peptide ligands -- binding agents -- that connect to receptors on mitochondria, which generate a cell's energy, and ribosomes, which process mRNA to make proteins.
The team found a peptide that binds to a specific ribosomal protein called RPL29 which, when delivered with penetratin, disrupts ribosomal function and kills cells. Cell survival was reduced in both malignant and non-malignant cells and in both mouse and human cell lines.Read more

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